AN EXPERIMENTAL METHOD FOR EVALUATING BLOOD SUBSTITUTES: REPORT ON SALINE, PLASMA, POLYVINYL ALCOHOL AND ISINGLASS

9 June 1944

journal article
research article
Published by American Association for the Advancement of Science (AAAS) in Science

Vol. 99 (2580) , 475-476
https://doi.org/10.1126/science.99.2580.475-a

Abstract

Shock was induced in rats by applying high tourniquets on both hind legs for 5 hrs. Ten ml. of a specific blood substitute were inj. intraven. into each rat 45 mins. after releasing the tourniquets. The animals were kept at 27-28[degree] C. Rats which received homologous plasma had a relatively low survival rate. Isotonic saline was slightly more effective than plasma. 4% isinglass in 0.85% saline gave the same results as saline. The effectiveness of treating shock with polyvinyl alcohol (Type RH623, du Pont) was striking.

This publication has 2 references indexed in Scilit:

STUDIES ON THERAPY IN TRAUMATIC SHOCK
American Journal of Physiology-Legacy Content, 1943
Experimental Chemotherapy of Burns and Shock. IV. Production of Traumatic Shock in Mice. V. Therapy with Mouse Serum and Sodium Salts
Public Health Reports®, 1943