The Effect of Chromomycin A3 upon Nucleic Acid Metabolism of Bacillus subtilisSB-15

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Abstract
Chromo- mycin A3 affects remarkably the pathway of RNA [ribonucleic acid] synthesis rather than those of DNA [deoxyribonucleic acid] and protein. The antibiotic acts also on the acid soluble fraction of the bacteria and causes a specific quantitative change of the nucleotide components. The amounts of guanine- and cytosine-nucleotides of treated bacteria increase more remarkably than those of adenine- and uracil-nucleotides. Chromomycin A3 inhibits more strongly the incorporation of radioactive precursors into 23 S RNA than into low molecular weight RNA.