Serotonin, memory, and the aging brain
- 1 February 1991
- journal article
- review article
- Published by Springer Nature in Psychopharmacology
- Vol. 103 (2) , 143-149
- https://doi.org/10.1007/bf02244194
Abstract
Serotonin is widely distributed throughout the central nervous system and is implicated in a variety of neural functions such as pain, feeding, sleep, sexual behavior, cardiac regulation and cognition. This paper is concerned with the last of these. Abnormalities of the serotonergic nervous system are well documented in pathologic studies of Alzheimer's disease and there is evidence suggesting that changes in this system occur in association with non-disease aging. Data on the role of serotonin in learning and memory and on the effects of aging on brain serotonin function are reviewed and discussed in relation to pharmacologic treatment strategies for the memory impairments associated with advancing age.Keywords
This publication has 77 references indexed in Scilit:
- Ultrastructural relationships of serotonin axon terminals in the cerebral cortex of the adult ratJournal of Comparative Neurology, 1989
- Altered modulatory actions of serotonin on dentate granule cells of aged ratsBrain Research, 1987
- Genotypic differences in central neurotransmitter responses to aging in miceNeurobiology of Aging, 1987
- Evidence for a possible functional interaction between serotonergic and cholinergic mechanisms in memory retrievalBehavioral and Neural Biology, 1987
- Age‐associated memory impairment: Proposed diagnostic criteria and measures of clinical change — report of a national institute of mental health work groupDevelopmental Neuropsychology, 1986
- Correlations between aminergic metabolites simultaneously obtained from human CSF and brainLife Sciences, 1985
- Monoamine activity correlates with psychometric deficits in Korsakoff's diseaseBehavioural Brain Research, 1985
- Effect of specific serotonergic lesions on cholinergic neurons in the hippocampus, cortex and striatumLife Sciences, 1983
- Effect of thiamine deficiency on brain serotonin turnoverBrain Research, 1979
- The alteration of serotonin binding sites in aged human brainLife Sciences, 1978