3RD-COMPONENT OF COMPLEMENT IN CYSTIC-FIBROSIS

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 28  (6) , 602-606
Abstract
In a study of C3 [3rd component of complement] levels and phenotypes in 64 cystic fibrosis (CF) patients, 92 CF parents, 64 normal siblings and 126 healthy controls, significant elevations of mean C3 levels were found in CF patients, their parents, and in 1 genetic subgroup of their siblings (SS females). C3 concentration in CF patients correlated with the degree of clinical impairment as measured by Shwachman-Kulczycki (S-K) score. No significant differences were found in the prevalences of C3 phenotypes or the S and F gene frequencies among the groups studied.