DIFFERENCES IN IMMUNE RESPONSE TO SYNTHETIC ANTIGENS IN 2 INBRED STAINS OF GUINEA-PIGS

  • 1 January 1967
    • journal article
    • research article
    • Vol. 12  (5) , 573-+
Abstract
The study of the immunogenicity of some linear and multichain synthetic polypetides in guinea-pigs, of inbred strains 2 and 13 led to their division into 3 categories: immunogenic in both inbred strains: linear copolymer of tyrosine, glutamic acid and alanine; immunogenic in strain 13 and negative in strain 2: linear copolymer of tyrosine and glutamic acid; and immunogenic in strain 2 and negative in strain 13: linear and branched copolymers containing lysine. No immune response was detected in strain 2 guinea-pigs to the copolymer of tyrosine, glutamic acid and lysine, composed only of the D-optical isomers. The immune response, or lack of response, in F1 hybrids of the inbred strains was identical with that of inbred strain 2 suggesting that the genetic determinants of this strain are dominant. No cross-reactions were observed at the delayed stage in inbred strain 2 between linear and multichain copolymers of similar composition.