Genetic linkage of mild malaria to the major histocompatibility complex in Gambian children: study of affected sibling pairs

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Abstract
We recruited 217 dizygous pairs of Gambian twins (mean age 5.3 years).3 Twins living together are important for such a study, for they are of the same age and share a common environment. They were monitored weekly during the 1991 rainy season for development of fever and P falciparum infection. Clinical malaria was defined as fever (axillary temperature ≥37.5°C) plus P falciparum asexual parasitaemia ≥5000/μl. Surveillance continued through the next two rainy seasons, producing a total of 40 pairs of twins who were concordant for clinical malaria; none had severe disease.

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