New 4-Aminoquinoline Mannich Base Antimalarials. 1. Effect of an Alkyl Substituent in the 5‘-Position of the 4‘-Hydroxyanilino Side Chain

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Abstract
A new series of 4-aminoquinoline Mannich base derivatives have been synthesized, in which the 3‘-diethylamino function of amodiaquine (AQ) is replaced by a 3‘-tert-butylamino group and an aliphatic hydrocarbon entity is incorporated into the 5‘-position of the 4‘-hydroxyanilino side chain. Seven alkyl Mannich base derivatives were screened and found to be active against both chloroquine-sensitive and -resistant strains of Plasmodium falciparum in vitro. The propyl and isopropyl alkyl derivatives were found to be the most active; consequently these derivatives were tested against a nonsensitive strain of Plasmodium berghi in vivo and found to be 3-fold more active than AQ, irrespective of the route of administration (oral or intraperitoneal).