Parental transmission of HLA-DRB1*15 in multiple sclerosis
- 31 October 2007
- journal article
- Published by Springer Nature in Human Genetics
- Vol. 122 (6) , 661-663
- https://doi.org/10.1007/s00439-007-0442-z
Abstract
Multiple sclerosis (MS) is a complex trait in which HLA-DRB1*15 bearing MHC haplotypes increase risk of MS in people of Northern European descent. In this investigation of 7,334 individuals from 1,515 MS families, the largest cohort used to study the HLA-DRB1 locus to date, we analysed the transmission of HLA-DRB1*15 haplotypes stratified by sex of transmitting parent. A significant over transmission of HLA-DRB1*15 from mothers was observed (χ 2 = 7.73, P = 0.0054), suggesting that parent of origin effects at the MHC determine susceptibility to MS.Keywords
This publication has 18 references indexed in Scilit:
- Parental transmission of MS in a population-based Canadian cohortNeurology, 2007
- The Inheritance of Resistance Alleles in Multiple SclerosisPLoS Genetics, 2007
- Mechanisms of Disease: the developmental origins of disease and the role of the epigenotypeNature Clinical Practice Endocrinology & Metabolism, 2007
- Maternal microchimerism in peripheral blood in type 1 diabetes and pancreatic islet β cell microchimerismProceedings of the National Academy of Sciences, 2007
- Two genes encoding immune-regulatory molecules (LAG3 and IL7R) confer susceptibility to multiple sclerosisGenes & Immunity, 2005
- DNA Methylation Profiling of the Human Major Histocompatibility Complex: A Pilot Study for the Human Epigenome ProjectPLoS Biology, 2004
- Parent-of-origin effect in multiple sclerosis: observations in half-siblingsPublished by Elsevier ,2004
- Properties of case/pseudocontrol analysis for genetic association studies: Effects of recombination, ascertainment, and multiple affected offspringGenetic Epidemiology, 2004
- Paternally inherited HLA alleles are associated with women's choice of male odorNature Genetics, 2002
- The multiple sclerosis‐ and narcolepsy‐associated HLA class II haplotype includes the DRB5*0101 alleleTissue Antigens, 1995