Dose-Dependence and Repeated-Dose Studies for Receptor/Gene-Mediated Pharmacodynamics of Methylprednisolone on Glucocorticoid Receptor Down-Regulation and Tyrosine Aminotransferase Induction in Rat Liver
- 1 January 1998
- journal article
- Published by Springer Nature in Journal of Pharmacokinetics and Biopharmaceutics
- Vol. 26 (6) , 619-648
- https://doi.org/10.1023/a:1020746822634
Abstract
Dose-dependent and repeated-dose effects of methylprednisolone (MPL) on down-regulation of glucocorticoid receptor messenger RNA (GR mRNA) and GR density, as well as tyrosine aminotransferase (TAT)...Keywords
This publication has 50 references indexed in Scilit:
- Corticosteroid effects in skeletal muscle: Gene induction/receptor autoregulationMuscle & Nerve, 1997
- Comparison of four basic models of indirect pharmacodynamic responsesJournal of Pharmacokinetics and Biopharmaceutics, 1993
- Pharmacoimmunodynamics of methylprednisolone: Trafficking of helper T lymphocytesJournal of Pharmacokinetics and Biopharmaceutics, 1992
- Drug- or hormone-induced adaptation: Model of adrenergic hypersensitivityJournal of Pharmacokinetics and Biopharmaceutics, 1989
- Second generation model for prednisolone pharmacodynamics in the ratJournal of Pharmacokinetics and Biopharmaceutics, 1989
- Evidence for kinetically distinct forms of corticosteroid 11β-dehydrogenase in rat liver microsomesThe Journal of Steroid Biochemistry and Molecular Biology, 1989
- Testing for the equality of area under the curves when using destructive measurement techniquesJournal of Pharmacokinetics and Biopharmaceutics, 1988
- Receptor-mediated pharmacodynamics of prednisolone in the ratJournal of Pharmacokinetics and Biopharmaceutics, 1986
- Extended least squares nonlinear regression: A possible solution to the “choice of weights” problem in analysis of individual pharmacokinetic dataJournal of Pharmacokinetics and Biopharmaceutics, 1984
- CorticosteroidsDrugs, 1978