Purification and Characterisation of a Small DNA‐Binding Protein, HB, from Bacillus globigii

Abstract
A small, heat-stable DNA-binding protein was purified from B. globigii: HB protein. The protein binds cooperatively to double-stranded DNA and the DNA-protein complexes are destabilized by the presence of moderate (0.1 M) levels of monovalent cations or by low levels (10 mM) of Mg2+. Two small DNA-binding proteins from Escherichia coli, NS1 and NS2, also known as HU protein, also were purified. Antibodies against all 3 proteins were prepared. All 3 are, by immunological criteria, related.