Effect of Injection of Foreign Bone Marrow on the Lymphatic Tissues of Normal Mice

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Abstract
Mice that received rat bone marrow intravenously as a primary or secondary injection showed marked cellular alterations in white pulp of the spleen and, to a lesser extent, in the other lymphatic tissues. The secondary response to rat marrow resembled an accelerated version of the primary response in the white pulp of the spleen. Throughout the white pulp, dissociated growth of Ab-forming cells, probably derived from germinal-center cells, was the characteristic cellular change. Hyperplasia of germinal centers in the spleen was present during the restitution phase. After an intravenous injection of homologous bone marrow, dissociated growth of Ab-forming cells was present in the white pulp. It lasted several days longer than the dissociated growth after injection of heterologous marrow. Hyperplastic germinal centers persisted for 6 weeks, and growth of the hyperplastic germinal centers characterized the secondary response to homologous marrow. Injection of isologous bone marrow did not cause changes in the white pulp of the spleen.