Selective lithiation of bis(azol-1-yl)methanes
- 1 January 1993
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 9,p. 1079-1083
- https://doi.org/10.1039/p19930001079
Abstract
Lithiation of bis(azol-1-yl)methanes and subsequent reaction with electrophiles yields selectively monoand di-ring-substituted derivatives. The regioselectivity observed is explained in terms of the structure of the substrate, the hard and soft acids and bases principle, and the nature of the electrophile used.Keywords
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