Population Pharmacokinetics of Gentamicin in Neonates

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Abstract
The influence of a number of clinical characteristics on the population pharmacokinetics of gentamicin were examined using routine drug-monitoring data from a group of 113 neonates. The data were analyzed using the programme NONMEM. Clearance was 0.053 litres∙h^-1∙kg^-1 and was reduced in neonates with postconceptional age <34 weeks (X 0.83) and 5-min Apgar score < 7 (X 0.82). Volume of distribution was 0.47 litres∙kg^-1. These population mean parameter estimates were used to generate dosage regimens to achieve concentrations within the therapeutic range.