ALLERGY AND LECTINS - INTERACTION BETWEEN IGE-MEDIATED HISTAMINE-RELEASE AND GLYCOPROTEINS FROM VISCUM-ALBUM L (MISTLETOE)

  • 1 January 1978
    • journal article
    • research article
    • Vol. 37  (10) , 1623-1628
Abstract
Low molecular constituents from V. album (toxic) released, in an irritatively toxic manner, histamine from human leukocytes without destroying the cells. This histamine release was prevented by preincubation with Viscum lectins. The Viscum lectin blocked the Fc-portion of allergen-specific Ig[immunoglobulin]E against anti-IgE [125I]. Lectin also inhibited the allergen-specific histamine release from human leukocytes occurring through IgE. This was demonstrated on leukocytes from patients with atopic extrinsic asthma. The inhibitory effect of lectin could also be due to a primary membrane effect, in addition to blockage of IgE.

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