PREDICTION OF INFUSION RATES: COMPUTER STUDY
Open Access
- 1 March 1990
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 64 (3) , 283-286
- https://doi.org/10.1093/bja/64.3.283
Abstract
The administration of two test doses in the ratio 1:0.5 has been shown to provide sufficient data (time intervals) to predict the infusion rate necessary to maintain the concentration of a drug at the therapeutic threshold in a two-compartment pharmacokinetic model. If the relationship between the durations of action of the test doses is linear, only one test dose may be needed to predict the infusion rate.Keywords
This publication has 2 references indexed in Scilit:
- INFUSION MODEL FOR FENTANYL BASED ON PHARMACOKINETIC ANALYSISBritish Journal of Anaesthesia, 1980
- General derivation of the ideal intravenous drug input required to achieve and maintain a constant plasma drug concentration. Theoretical application to lignocaine therapyEuropean Journal of Clinical Pharmacology, 1976