The Effects of Ionizing Radiations on Endocrine Cells: IV. Increased Production of 17α, 20α-Dihydroxyprogesterone in Rat Testes after Irradiation

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Abstract
Rat testicular tissue mince was incubated with progesterone-4-Cl4. From the incubation mixture, 17[alpha], 20[alpha]-dihydroxyprogesterone was isolated and characterized as one of the main steroids of a high-polar steroid fraction. Biosynthesis of this steroid has been shown to be altered after various modes of irradiation. It would appear that the in vitro biosynthesis of 17[alpha], 20[alpha]-dihydroxyprogesterone is related to the physiologic state of the testis. When 17[alpha], 20[alpha] -dihydroxyprogesterone was incubated with mouse testicular tissue, only small amounts of this steroid were biotransformed into 17[alpha]-hydro-xyprogesterone, androstenedione and testosterone.