Cultivation of Toxoplasma in Embryonated Egg. An Antigen Derived from Choriolallantoic Membrane
- 1 January 1948
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 67 (1) , 85-89
- https://doi.org/10.3181/00379727-67-16213
Abstract
Inoculation of Toxoplasma into the chorioallantoic space of 8- to 10-day embryonated eggs resulted in a fatal parasitemia in approx. 8 days. The organisms were numerous in the brain and chorioallantoic membranes, and regularly produced macroscopic lesions in the latter. A complement-fixing antigen was prepared from infected chorioallantoic membranes which gave specific reactions with high dilutions of hyperimmune monkey and guinea pig sera. This antigen also reacted with human convalescent sera from cases of clinical toxoplasmosis. It elicited a cutaneous reaction in one adult patient in whom complement-fixing and neutralizing antibodies for Toxoxlasma were also present.This publication has 0 references indexed in Scilit: