Role of autacoids in cardiovascular collapse in anaphylactic shock in anesthetized dogs
- 1 July 1999
- journal article
- Published by Oxford University Press (OUP) in Cardiovascular Research
- Vol. 43 (1) , 173-182
- https://doi.org/10.1016/s0008-6363(99)00073-5
Abstract
Objective: In anaphylactic shock (AS), the relative effects of the autacoids including histamine, prostaglandins (prost), and leukotrienes (leuk) on causing cardiovascular collapse and the extent to which receptor blocking agents and pathway inhibitors may prevent this collapse are not clear. Methods: In randomized design, we investigated whether blockade of histamine H1, H2, and H3 receptors or inhibition of the cyclooxygenase (cyclo) and lipoxygenase pathways (lipox) prevented AS in ragweed sensitized dogs. Seven dogs were studied under pentobarbital anesthesia in which the treatment studies were approximately 2 weeks apart. Results: During H1 receptor blockade, the decreases in blood pressure and cardiac output otherwise observed in AS were attenuated (PConclusion: H1 receptor blockade and cyclo may attenuate cardiovascular shock in AS. These agents inhibit autacoid release from mast cells in addition to any specific receptor blocking and pathway inhibition effects.Keywords
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