Particle Filtration for Determination of Pore Size Characteristics of Microporous Membranes: Applicability to Plasma Separation Membranes

Abstract
Pore characteristics of microporous membranes were studied by filtration with aqueous solutions containing spherical particles of uniform diameter. The rejection values for four types of plasma separation membranes of microporous structure show good linearity to particle size with high correlation on log-normal probability coordinates. The mean pore size of 94 to 866 Å and standard deviation of 1.51 to 2.13 were obtained for these membranes. Such membranes have mean pore sizes of about one order of magnitude larger than that for synthetic dialysis and hemofiltration membranes in addition to having wider pore distributions. The mean pore sizes obtained by this study relate closely to sieving properties of macromolecules from blood.

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