Lifetime Cigarette Smoking and Colorectal Cancer Incidence in the Physicians' Health Study I

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Abstract
Colorectal cancer ranks fourth in incidence and second in cause of death from cancer in the United States (1). Although virtually every study has reported a positive association between cigarette smoking and adenomatous polyps, the evidence regarding smoking and colorectal cancer is less clear, probably because of a long induction period (2). We, therefore, examined lifetime smoking history and incidence of colorectal cancer in a large cohort of men followed for more than 12 years.