White matter dementia in chronic toluene abuse
- 1 March 1990
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 40 (3_part_1) , 532
- https://doi.org/10.1212/wnl.40.3_part_1.532
Abstract
We studied 14 chronic toluene abusers with a comprehensive neuropsychological evaluation and cerebral magnetic resonance imaging (MRI). There were 10 men and 4 women, and the mean age was 29 years. Using a blinded global assessment of neuropsychological functioning, we found 3 patients to be normal, 3 in a borderline range, and 8 impaired. Independent analyses of white matter changes on MRI disclosed that the degree of white matter abnormality was strongly correlated (p < 0.01) with neuropsychological impairment. Dementia in toluene abuse appears to be related to severity of cerebral white matter involvement.Keywords
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