CYCLOSPORIN-A - INDUCED INCREASES IN RENIN STORAGE AND RELEASE
- 1 January 1982
- journal article
- research article
- Vol. 37 (2) , 305-312
Abstract
The effect of Cyclosporin A (CyA) [an immunosuppressive drug] on renin storage and release in rats was investigated. Renin release from incubated renal cortical slices was increased in rats treated with 25 or 50 mg/kg per day of CyA for 3-7 days. This was associated with an increase in renal cortical renin content, which was also increased over the same time period. Plasma renin activity was similarly elevated in these rats. These increases in renin may be related to CyA nephrotoxicity.This publication has 6 references indexed in Scilit:
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