Liver Pyridine Nucleotide Synthesis in the Vitamin B6-Deficient Rat.

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Abstract
Vitamin B6-deficient and pair -fed or ad libitum-fed control rats were injected with nicotinic acid or nicotinamide to determine whether vitamin Bg deficiency affected the ability of the rat to synthesize liver pyridine nucleotides. Vitamin Bg deficiency could impair liver pyridine nucleotide synthesis by interfering with the production of purines via glycine and formate. At 10 hours after the injection of either nicotinic acid or nicotinamide, liver pyridine nucleotide synthesis was significantly lower in the vitamin B6-deficient rats than in the vitamin B6-supplemented rats. Pyridine nucleotide values were also significantly lower in the deficient rats at 1 and 4 hours after the injection of nicotinic acid but not after the injection of nicotinamide.

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