Diastolic Hypertension Produced by High Fat Diets and Dietary Stresses.

Abstract
Four normal dogs were subjected to prolonged preliminary fast and realimentation with diets containing from 50 to 70% of the calories from beef suet and butter fed at levels ranging from 60 to 120 cal/Meter2/hr. These "fat episodes" were repeated 6 times in 14 months in the first experimental period and 3 times in 10 months in the 2d period. The "fat episodes" were combined with high calorie diets to produce marked obesity and with low calorie diets to cause pronounced weight loss. As a result of these dietary stresses the animals developed a highly significant diastolic hypertension which is still present when on the standard kennel diet of Nutrena 34 months after the first "fat episode".