REPRESSED GROWTH OF C57BL MARROW IN HYBRID HOSTS REVERSED BY ANTISERA DIRECTED AGAINST NON-H-2 ALLOANTIGENS

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Abstract
The growth of C57BL hemopoietic colony-forming cells is repressed in irradiated (C57BL X C3H)F1 hybrid hosts. This effect is known to be associated with heterozygosity at the H-2 locus in the recipient. We have observed an increase in the colony-forming efficiency of transplanted C57BL cells following treatment of the hosts with appropriate alloantisera (derepression). Specificity requirements for both the antigen donor and the antibody producer indicate that differences at the H-2 locus are neither necessary nor sufficient for the generation of derepressive alloantisera.

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