Genotype dependent and cigarette specific effects on endothelial nitric oxide synthase gene expression and enzyme activity
Open Access
- 5 April 2000
- journal article
- Published by Wiley in FEBS Letters
- Vol. 471 (1) , 45-50
- https://doi.org/10.1016/s0014-5793(00)01356-9
Abstract
We explored the interactive effects of endothelial nitric oxide synthase (eNOS) genotypes and cigarette smoking on protein levels and enzyme activity in 33 postpartum placentas. Whilst the eNOS protein levels were lower in the rare allele (0.48±0.11, n=9 vs. 1.05±0.10, n=24, PPPn=5, smokers: 2968.5±259.4, n=4, 52% reduction, P<0.01). We conclude that associations between eNOS polymorphism and protein levels and enzyme activities are modifiable by smoking, the effects of smoking are dependent on the eNOS genotypes.Keywords
This publication has 25 references indexed in Scilit:
- T −786 →C Mutation in the 5′-Flanking Region of the Endothelial Nitric Oxide Synthase Gene Is Associated With Coronary SpasmCirculation, 1999
- Polymorphisms of the endothelial nitric oxide synthase gene — no consistent association with myocardial infarction in the ECTIM studyEuropean Journal of Clinical Investigation, 1999
- Reduced Endothelial Nitric Oxide Synthase Expression and Production in Human AtherosclerosisCirculation, 1998
- NITRIC OXIDE SYNTHASE: Role in the Genesis of Vascular DiseaseAnnual Review of Medicine, 1997
- Regression or ProgressionArteriosclerosis, Thrombosis, and Vascular Biology, 1996
- CA Repeat Polymorphism of the Endothelial Nitric Oxide Synthase Gene in the JapaneseHuman Heredity, 1995
- Nitric oxide synthase: Aspects concerning structure and catalysisCell, 1994
- NO at workCell, 1994
- Cloning and structural characterization of the human endothelial nitric‐oxide‐synthase geneEuropean Journal of Biochemistry, 1994
- Molecular cloning and characterization of human endothelial nitric oxide synthaseFEBS Letters, 1992