COMPARISON OF THE VOLUME OF DISTRIBUTION, RENAL AND EXTRARENAL CLEARANCES OF INULIN AND MANNITOL IN MAN 1

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Abstract
The volumes of distribution, total plasma clearance and renal clearance of mannitol and inulin were measured simultaneously in subjects without evident abnormalities of hydration. Close correspondence between the inulin space measured by the infusion-recovery method and the mannitol space measured by the infusion-slope method attests the validity of both methods for measuring the extracellular fluid volume. Mannitol disappears from the extracellular fluid by extrarenal as well as renal mechanisms, although in some individuals the degree of extrarenal disposal is small. The mannitol/inulin renal clearance ratio averaged 0.89 [plus or minus] 0.05 in 20 subjects.