AIRWAY HYPERRESPONSIVENESS AND CHANGES IN CELL COUNTS IN BRONCHOALVEOLAR LAVAGE AFTER OZONE EXPOSURE IN DOGS

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  • 1 January 1984
    • journal article
    • research article
    • Vol. 129  (2) , 288-291
Abstract
Whether airway hyperresponsiveness induced by O3 exposure was associated with changes in the numbers of different types of cells in bronchoalveolar lavage in dogs was studied. Airway responsiveness to acetylcholine and the numbers of cells in lavage fluid were determined 1 wk before, and 1 h and 1 wk after 2 h exposures to filtered air, and to O3 (3.0 ppm) in 5 dogs. Airway responsiveness and the numbers of cells in lavage fluid did not change after exposure to filtered air. Airway responsiveness increased markedly 1 h after exposure to O3 and returned to control levels 1 wk later. The numbers of neutrophils, and of ciliated epithelial cells in lavage increased markedly 1 h after O3 and returned to control levels 1 wk later. Airway hyperresponsiveness induced by O3 was associated with an influx of neutrophils into the most central airways. Hyperresponsiveness was also accompanied by an influx of neutrophils into more distal airways and by desquamation of airway epithelial cells.

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