Effect of Cycloheximide and Chloramphenicol on 6-Methylcoumarin Induced Chromosome Breakage inAllium Cepa

Open Access

1 January 1969

journal article
research article
Published by Firenze University Press in Caryologia

Vol. 22 (4) , 375-378
https://doi.org/10.1080/00087114.1969.10796357

Abstract

The influence of the protein synthesis inhibitors cycloheximide (CHI) and chloramphenicol (CHL) on the chromosome breaking action of 6-methylcoumarin (6-MC) was investigated on Allium cepa root meristems. Both inhibitors, when applied as a post-treatment, strikingly increased the frequency of subchromatid exchanges, chromatid breaks and achromatic lesions induced by 6-MC. The possible implications of such findings in relation to the mechanism of induction of chromosome aberrations in G₂ (DNA post-synthetic phase) and of chiasma formation in meiosis are discussed.

Keywords

This publication has 3 references indexed in Scilit:

EFFECT OF HYDROXYUREA AND OTHER INHIBITORS OF DNA SYNTHESIS ON VICIA CHROMOSOMES PREVIOUSLY EXPOSED TO X-RAYS OR TO RADIOMIMETIC CHEMICALS
Hereditas, 2009
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The effect of chloramphenicol on the chromosome-breaking action of 8-ethoxycaffeine and 6-methylcoumarin in Vicia faba
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