Metabolic oxidation of desmethylchlorimipraminein vitroby 9000grabbit-liver preparations

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Abstract
The metabolism of demethylchlorimipramine [an antidepressant] was investigated in vitro using fortified 9000 g liver homogenates of male rabbits. Four metabolic products: N-hydroxydemethylchlorimipramine, 3-(3-chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propanoic acid, 10/11-hydroxydemethylchlorimipramine and 2/8-hydroxydemethylchlorimipramine were isolated and identified by electron-impact mass spectrometry and NMR spectroscopy. Demethylchlorimipramine undergoes both N- and .alpha.-carbon oxidation in addition to aromatic and alicyclic carbon oxidation.