Effect of surugatoxin on celiac ganglia in cats

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Abstract
Pharmacological properties of surugatoxin (SGTX), the toxic principle from Japanese ivory mollusc (Babylonia japonica), were studied. The effect of SGTX of celiac ganglia in cats was investigated by measuring blood pressure from the femoral artery and regional blood flow in the liver (LBF) and spleen (SBF) of anesthetized cats. SGTX (50 nmol/kg i.v.) markedly inhibited both the hypertension and changes of LBF and SBF in response to splanchnic (preganglionic) nerve stimulation. On the other hand, it did not inhibit the changes of SBF of splenic (postganglionic) nerve stimulation. The hypertension and changes in LBF and SBF in response to DMPP [1,1-dimethyl-4-phenylpiperazinium iodide] (94.2 nmol/kg i.v.) was abolished by SGTX (50 nmol/kg i.v.), whereas those to McN-A-343 [4-(m-chlorophenylcarbamoyloxy)-2-butynyltrimethylammonium chloride] (94.8 nmol/kg i.v.) were not. SGTX usually enhanced the pressor response to McN-A-343. SGTX has a blocking effect on the nicotinic receptor in the celiac ganglia and in the superior cervical ganglia of cats and rats.