Familial Hypopituitarism with Large Sella Turcica

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Abstract
We studied endocrine function in three siblings with short stature and enlargement of the sella turcica. Sellar volumes were 5.9, 3.7 and 4.0 standard deviations above age-specific means. Computed tomography or pneumoencephalography showed full sellae without suprasellar extension. Basal thyrotropin levels were low despite hypothyroidism and increments were <3 μU per milliliter after thyrotropin-releasing hormone injection. Stimulated growth hormone levels were <5 ng per milliliter, declining to <2 ng per milliliter after thyroxine treatment. Both thyroxine and growth hormone treatments were required for rapid growth.

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