Many rhinovirus serotypes share the same cellular receptor

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Abstract
Human rhinovirus serotypes were grown and purified by centrifugation in metrizamide density gradients. These 24 preparations had a lower buoyant density (1.24 g/cm3) and higher specific infectivities (1:24 to 1:240) than did rhinoviruses described previously. Binding conditions in which the unique cellular receptors [on human cervical carcinoma HeLa R-19 cells] for virus attachment were saturated were determined for each serotype. Competition binding assays between pairs of serotypes allowed 20 of the 24 serotypes to be assigned to the same cellular receptor. The remaining 4 serotypes appeared to attach to a different cellular receptor. Since most serotypes were chosen for study at random, many of the yet unstudied rhinoviruses will probably share this common cellular receptor.