Lymphocyte 5′-ectonucleotidase: an indicator of oxidative stress in humans?
- 1 April 2000
- journal article
- Published by Taylor & Francis in Redox Report
- Vol. 5 (2) , 89-91
- https://doi.org/10.1179/135100000101535618
Abstract
Lymphocytic 5'-ectonucleotidase (NT) activity previously has been shown to be reduced in patients with a high pro-oxidant state. This study shows that NT activity is decreased in vitro by exposure to superoxide anions and that ascorbate protects against this effect. Also, a putative high pro-oxidant state in vivo, as indicated by low tissue ascorbate levels, resulted in a significant decrease in NT which an antioxidant intake normalized. These results taken together suggest that NT is sensitive to superoxide anion and that it may be a good marker of a pro-oxidant state in humans.Keywords
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