Discovery of Anticancer Agents from Natural Products
- 1 January 1995
- journal article
- research article
- Published by Taylor & Francis in International Journal of Pharmacognosy
- Vol. 33 (sup1) , 59-66
- https://doi.org/10.3109/13880209509067088
Abstract
Cellular in vitro assays have been both developed and employed by us to search for new, solid tumor specific anticancer agents. Parallel in vivo models are then used to assess the therapeutic efficacy of candidates selected by the in vitro assays. During the past 4 years, extracts as well as pure compounds from natural products have been obtained from collaborators at the University of Hawaii and Lilly Research Laboratories. The samples have been analyzed, the structures identified and a number of lead compounds proposedKeywords
This publication has 5 references indexed in Scilit:
- Marine Natural Products Research: A Look into the Dive BagJournal of Natural Products, 1995
- Total Structures of Cryptophycins, Potent Antitumor Depsipeptides from the Blue-Green Alga Nostoc sp. Strain GSV 224Journal of the American Chemical Society, 1994
- Anticancer Drug Discovery and Development: Natural Products and New Molecular ModelsPublished by Springer Nature ,1994
- Discovery of Solid Tumor Active Agents Using a Soft-Agar-Colony-Formation Disk-Diffusion-AssayPublished by Springer Nature ,1992
- Is the P388 murine tumor no longer adequate as a drug discovery model?Investigational New Drugs, 1987