Constitutive Fragile Sites and Cancer
- 7 December 1984
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 226 (4679) , 1199-1204
- https://doi.org/10.1126/science.6239375
Abstract
Breaks were observed at 51 sites in homologous chromosomes in lymphocytes from ten humans and two great apes when cells were deprived of thymidine. The incidence of breaks was enhanced by caffeine, a substance that inhibits DNA repair in replicating cells. The locations of 20 sites were correlated with breakpoints that have been related to human malignancy.This publication has 29 references indexed in Scilit:
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