Intra-Arterial Cisplatin Treatment of Unresectable or Medically Inoperable Invasive Carcinoma of the Bladder

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Abstract
Patients (5), 72-82 yr old, received 5-6 treatments of 50-75 mg per m2 cisplatin by bilateral internal iliac artery infusion for unirradiated invasive transitional cell carcinoma of the bladder. Of the patients 3 also were diabetics and 1 had congestive heart failure. Treatment was tolerated extremely well, although most courses were associated with moderate to severe nausea and vomitng lasting several hours. Of 4 evaluable patients 3 achieved complete remission and 1 achieved a good partial remission. An additional 55-yr-old woman with a large invasive bladder carcinoma fixed to surrounding structures was treated with 4 courses of 100 mg per m2 intra-arterial cisplatin. This patient had a marked decrease in tumor size, permitting surgical resection of all known residual tumor. A 49-yr-old patient with large pelvic lymph node metastases from a squamous cell carcinoma of the bladder achieved only minimal decrease in tumor size after 3 courses of 100 mg per m2 intra-arterial cisplatin. Intra-arterial cisplatin can be highly effective for localized invasive bladder cancer even when relatively low doses are used. With proper care the regimen can be used safely and effectively in elderly patients with medical contraindications to an operation.