Long-term Removal of 241Am Using Ca-DTPA
- 1 October 1980
- journal article
- research article
- Published by Wolters Kluwer Health in Health Physics
- Vol. 39 (4) , 601-609
- https://doi.org/10.1097/00004032-198010000-00002
Abstract
This report considers a 12-yr study of an individual exposed to 241Am. Chelation therapy, with CaNa3 DTPA, over a span of 6.5 yr resulted in removal of in excess of 1 μCi of 241Am. During therapy the total body burden decreased as a two component exponential with half lives of approx. 0.79 and 24 yr. During DTPA treatment with 1 g(week, average urinary excretion rates were increased to 10 times unchelated levels. Of the approx. 0.7 μCi remaining, the largest fraction appears to be confined to the skeleton. Clearance patterns during and following chelation are discussed. Clinical observations, including tests of liver and kidney function, hematology and cytogenetics showed na adverse effects from the long term DTPA therapy or 241Am exposure.This publication has 0 references indexed in Scilit: