Increased brainstem excitability in stiff-person syndrome
- 13 August 2002
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 59 (3) , 449-451
- https://doi.org/10.1212/wnl.59.3.449
Abstract
The recovery cycle of the R2 component of the blink reflex was studied in five patients with stiff-person syndrome (SPS) and in seven healthy control subjects. R2 recovery was enhanced in patients with SPS. This result is suggestive of hyperexcitability of brainstem interneuronal circuits in SPS. Hyperexcitability may result from abnormal input from suprasegmental structures or loss of inhibition by interneurons and is compatible with the proposal that there is a widespread dysfunction of central inhibitory mechanisms in SPS.Keywords
This publication has 9 references indexed in Scilit:
- Motor cortex excitability in stiff-person syndromeBrain, 2000
- The Stiff-Person Syndrome: An Autoimmune Disorder Affecting Neurotransmission of γ-Aminobutyric AcidAnnals of Internal Medicine, 1999
- An Explanation for Reflex Blink Hyperexcitability in Parkinson’s Disease. I. Superior ColliculusJournal of Neuroscience, 1996
- Changes in the balance between motor cortical excitation and inhibition in focal, task specific dystonia.Journal of Neurology, Neurosurgery & Psychiatry, 1995
- Stiff man syndrome: neurophysiological findings in eight patientsZeitschrift für Neurologie, 1995
- AAEM minimonograph #44: Diseases associated with motor unit activityMuscle & Nerve, 1994
- Recovery curves of the blink reflex during wakefulness and sleepZeitschrift für Neurologie, 1976
- DISORDER OF INTERNEURONS IN PARKINSONISMBrain, 1973