Membrane-Anchored Peptide Inhibits Human Immunodeficiency Virus Entry

Open Access

15 March 2001

journal article
Published by American Society for Microbiology in Journal of Virology

Vol. 75 (6) , 3038-3042
https://doi.org/10.1128/jvi.75.6.3038-3042.2001

Abstract

Peptides derived from the heptad repeats of human immunodeficiency virus (HIV) gp41 envelope glycoprotein, such as T20, can efficiently inhibit HIV type 1 (HIV-1) entry. In this study, replication of HIV-1 was inhibited more than 100-fold in a T-helper cell line transduced with a retrovirus vector expressing membrane-anchored T20 on the cell surface. Inhibition was independent of coreceptor usage.

Keywords

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