5-Fluorouracil, Doxorubicin, and Mitomycin (FAM) Combination Chemotherapy for Advanced Gastric Cancer

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Abstract
Patients [62] with advanced, measurable gastric cancer were treated with a combination chemotherapy program of 5-fluorouracil, doxorubicin and mitomycin (FAM). Of these patients, 42% achieved an objective partial response. The median duration of remission was 9 mo. and the median survival for responding patients, 12.5 mo. The median survival for nonresponding patients was 3.5 mo.; all patients were dead by 8 mo. after initiation of therapy. The median survival of all 62 patients treated with FAM was 5.5 mo. An analysis of possible prognostic variables, including initial performance status, resectability of the primary gastric tumor and histologic differentiation of the neoplasm, failed to account for differences in patient response and survival. The FAM regimen was well tolerated, producing only moderate bone marrow suppression. Patients with metastatic gastric cancer can be effectively palliated with FAM chemotherapy. The efficacy of this regimen should now be tested in patients with less advanced stages of this disease.

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