Changes in Flow Resistance in Kidney Vessels of Dogs by Hypothermic Hyperosmotic Perfusion

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Abstract
Dog kidneys have been cold perfused by gravity and by nonpulsatile pressure after 24 h preservation time at 5 °C with normotonic Ringer’s solution without drugs, Ringer’s solution containing furosemide (10mg/l), acetylcholine (100mg/l), phentolamine (10mg/l) or dopamine (0.2, 2 and 20 mg/l), and Ringer’s solution made hypertonic (400 and 500 mosm/l) with glucose, mannitol, choline chloride or urea. Addition of the described drugs to normotonic Ringer’s produced no detectable change in the perfusion rate. In contrast, a significant flow increase was constantly observed when perfusion was made with hypertonic Ringer’s solutions. Flow increase was found to be dependent on the osmolarity of the perfusate but not on the kind of solute used to raise it.

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