Efficacy of ?-diketonato complexes of titanium, zirconium, and hafnium against chemically induced autochthonous colonic tumors in rats
- 1 August 1987
- journal article
- research article
- Published by Springer Nature in Zeitschrift für Krebsforschung und Klinische Onkologie
- Vol. 113 (5) , 446-450
- https://doi.org/10.1007/bf00390038
Abstract
Bis-β-diketonato complexes of titanium, zirconium, and hafnium were tested against autochthonous colorectal tumors in rats. The model was found to reflect the clinical situation most closely. of the compounds tested, budotitane was the most effective in terms of decrease in tumor weight and number and in increasing the lifespan of the treated animals. The therapeutic efficiency was superior to that of 5-fluorouracil, which so far has been the drug with the best activity in patients suffering from colon cancer.Keywords
This publication has 11 references indexed in Scilit:
- Autochthonous, acetoxymethylmethylnitrosamine-induced colorectal cancer in rats: a useful tool in selecting new active antineoplastic compounds?1986
- PRECLINICAL EVALUATION OF DICHLOROBIS(1-PHENYLBUTANE-1,3-DIONATO)TITANIUM(IV) AND BUDOTITANE - 2 REPRESENTATIVES OF THE NEW CLASS OF ANTITUMOR-ACTIVE BIS-BETA-DIKETONATO METAL-COMPLEXES1986
- Antitumor activity of phenyl substituted dihalogenobis (1-phenyl-1,3-butanedionato)titanium (IV) compounds.1985
- Antitumor activity of 1.3-diketonato zirconium (IV) and hafnium (IV) complexes.1985
- Antitumor activity of cis-dihalogenobis(1-phenyl-1,3-butanedionato)titanium(IV) compoundsZeitschrift für Krebsforschung und Klinische Onkologie, 1983
- Chemotherapeutic studies on N-nitrosoacetoxymethyl-methylamine-and 1,2-dimethylhydrazine-induced colonic tumors in rats: Monotherapy with 5-fluorouracil, ftorafur, CGP 6809, and CGP 15'720AZeitschrift für Krebsforschung und Klinische Onkologie, 1982
- Stereochemistry and lability of dihalobis(.beta.-diketonato)titanium(IV) complexes. II. Benzoylacetonates and dibenzoylmethanatesInorganic Chemistry, 1967
- Nonparametric Estimation from Incomplete ObservationsJournal of the American Statistical Association, 1958
- Errata: Use of Ranks in One-Criterion Variance AnalysisJournal of the American Statistical Association, 1953
- Use of Ranks in One-Criterion Variance AnalysisJournal of the American Statistical Association, 1952