New Diagnostic Methods in Prostatic Cancer: I. Investigation of the Chromatographic Adsorption Technique for Qualitative Analysis of Urinary 17-Ketosteroids

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Abstract
The excretory patterns of the urinary 17-ketosteroids were detd. chromatographically, using the Callow modification of the Zimmermann reaction, in 9 patients with prostatic cancer, 5 patients with benign prostatic hyper-plasia, and 4 normal aging males. Reproducibility of the method was obtained. Five well defined elevations were demonstrated for all patients studied, indicating little qualitative difference in the urinary steroid pattern under the conditions of the method. Quantitative differences were observed; patients with benign prostatic hyperplasia showed higher values for total 17-keto-steroids and individual eluate totals than either patients with prostatic cancer or, in turn, normal aging males. In the differential diagnosis of prostatic neoplasia, the method described appears to be of little value.