THE RATE OF OXYGEN UTILIZATION BY RAT KIDNEYS AT DIFFERENT RATES OF UREA EXCRETION

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Abstract
The work of urea excretion per min. and the rate of O2 uptake of rats anesthetized with pentobarbital, before and directly after clamping the renal pedicle, was determined in 32 pairs of rats, half of which had been on a diet of 10% dextrose and half on 10% dextrose and 10% urea. Per gm. of kidney, the rate of work done in excreting urea was 0.00075 cal. per min. in rats on dextrose, 0.043 in those on urea; renal metabolism, per gram per min., was 0.92 cal. in the first group, 1.13 in the second. The total increase in O2 absorption by rat kidney is 5 times greater than caloric equivalent of the work done in excreting extra urea, but the percentage increase in O2 absorption is insignificant in comparison with the percent increase in work. Only 1 to 4% of the total specific dynamic action of protein can be due to the extra renal work of N excretion.

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