DNA Polymerase Required for Rapid Repair of X-ray—Induced DNA Strand Breaks in vivo
- 21 May 1971
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 172 (3985) , 851-854
- https://doi.org/10.1126/science.172.3985.851
Abstract
A much higher yield of DNA single-strand breaks was obtained in the DNA polymerase-deficient mutant Escherichia coli K-12 pol A1 after a given dose of x-rays than had been found before in Escherichia coli. The increased yield of single-strand breaks was due to the absence of a rapid repair system, which had not been described in Escherichia coli K-12. This absence probably accounts for the x-ray sensitivity of the pol A1 mutant. The rapid repair system can be reversibly inhibited in pol+ cells.Keywords
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