Vitrectomy for Prevention of Macular Hole Study

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Abstract
To the Editor. —I read with interest the letter and reply by Gass1and Trempe,2respectively, on the risk of developing a macular hole. In discussing vitrectomy for early stages of macular holes, Trempe states, "... this subject is in urgent need of a randomized study. Such a study would be greatly enhanced if Dr Gass were involved in its planning." I would like to remind Trempe and the readers of theArchivesthat such a study is under way, with Gass to serve as a consultant, as discussed in an editorial in theArchives.3Contrary to some pervasive ideas, I believe that, at this time,there is no evidence whatsoever that vitreous surgery is beneficial in preventing macular holes. I encourage ophthalmologists to refer appropriate patients to participating centers, where study patients with symptomatic fellow eyes with stage 1 macular holes are randomized to undergo vitrectomy vs

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