The Role of Regional Body Temperature in the Pathogenesis of Disease

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Abstract
WHY do the lesions of secondary syphilis affect the skin, classically over the palms and soles? Why do the lesions of leprosy predominantly affect the hands, feet, ear, nose, and extensor surfaces? Why does mucocutaneous leishmaniasis affect the ear, nasal septum, and distal extremities, whereas kala-azar afflicts the internal viscera? Why does the rash of Rocky Mountain spotted fever characteristically begin over the wrists and ankles, spread to the palms and soles, and then move centripetally, whereas the rash of typhus begins over the axilla and trunk? Why do the lesions of smallpox appear selectively over the hands and feet, . . .