Response to Comment on "Reelin Promotes Peripheral Synapse Elimination and Maturation"

Publisher Website
Google Scholar
Abstract
My findings agree with those of Bidoia et al. (2). Consistent with their observations, I saw no evidence of supernumerary synapses in reeler muscle fibers. I also did not observe the reported high frequency of polyneuronal innervation of reeler end plates, despite the use of approaches and conditions similar to those used by Quattrocchi in (1). Thus, our published report indicating the involvement of Reelin in synapse elimination clearly appears to be in error. This raises serious doubts concerning the ability of exogenous Reelin to promote axonal withdrawal in a manner dependent on its reported serine protease activity (1, 3).