Paternal origin of the de novo deleted chromosome 4 in Wolf-Hirschhorn syndrome.
Open Access
- 1 January 1992
- journal article
- research article
- Published by BMJ in Journal of Medical Genetics
- Vol. 29 (1) , 53-55
- https://doi.org/10.1136/jmg.29.1.53
Abstract
The parental origin of the de novo deleted chromosome 4 was studied in five cases of Wolf-Hirschhorn syndrome using polymorphic probes mapping in the 4p16.3 region. In all the patients the deleted chromosome was found to be of paternal origin and these results, together with similar ones obtained by another group, make the preferential paternal origin of the de novo chromosome 4 deletion highly significant.Keywords
This publication has 10 references indexed in Scilit:
- Paternal origin of the chromosomal deletion resulting in Wolf-Hirschhorn syndrome.Journal of Medical Genetics, 1991
- Genomic imprinting: review and relevance to human diseases.1990
- Comparison of the 15q deletions in Prader‐Willi and Angelman syndromes: Specific regions, extent of deletions, parental origin, and clinical consequencesAmerican Journal of Medical Genetics, 1990
- Report of the committee on the genetic constitution of chromosome 4Cytogenetic and Genome Research, 1990
- Genomic imprinting and genetic disorders in manTrends in Genetics, 1989
- Genomic imprinting: a possible mechanism for the parental origin effect in Huntington's chorea.Journal of Medical Genetics, 1988
- Wolf-Hirschhorn locus is distal to D4S10 on short arm of chromosome 4.Journal of Medical Genetics, 1987
- The critical monosomic segment involved in 4p- syndrome: A high-resolution banding study on five inherited casesJournal of Human Genetics, 1984
- A technique for radiolabeling DNA restriction endonuclease fragments to high specific activityAnalytical Biochemistry, 1983
- High resolution R- and G-banding on the same preparationHuman Genetics, 1981